Antimicrobial resistance is a major problem today in which early detection and susceptibility of a pathogen
could dictate the proper course of treatment and outcome of infection. Our group focuses on understanding
the molecular mechanisms involved in antimicrobial resistance in addition to developing novel molecular pointof-care and in-house diagnostic tests to identify susceptibility in bacterial, fungal, and parasitic pathogens.
Currently our research interests involve three main projects. First, we are investigating the mechanisms involved
in penicillin tolerance in a gram-positive bacterium, Group B Streptococcus. This opportunistic pathogen is
a leading cause of life-threatening infections in neonates and recently has presented itself as an emerging
pathogen in the elderly. The second project involves investigating the mechanisms of azole resistance
amongst Candida species, in particular Candida glabrata. Candida infections, in particular C. albicans and
C. glabrata, are the leading cause of fungal infections that can affect both healthy (yeast infections in women)
and immune compromised (patients with HIV/AID or undergoing chemotherapeutic or immune suppressive
therapy) individuals. The third project involves the development of point-of-care diagnostic tests for GBS and
Methicillin Resistant Staphylococcus aureus (MRSA), a major healthcare problem due to the level of morbidity
and mortality from community and hospital acquired infections. Investigating these mechanisms in bacteria and
fungi can lead to improved diagnostics and targets for new antimicrobial compounds.
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