Medical Diagnostic Laboratories - a CLIA certified infectious disease laboratory with multiple state licenses specializing in PCR technology.

Antimicrobial Resistance Division

Research Personnel Publications & Abstracts

Publications

1. Gygax SE, Schuyler JA, Kimmel LE, Trama JP, Mordechai E, Adelson, ME. 2006. Erythromycin and clindamycin resistance in Group B Streptococcal clinical isolates. Antimicrob Agents Chemother,
50(5):1875-7.

2. Gygax SE, Schuyler JA, Trama JP, Mordechai E, Adelson ME. 2007. The detection of erythromycin and clindamycin resistance genes in both Group B Streptococcal clinical isolates and cervicovaginal/rectal swabs. Microb Drug Resist, 13(2):119-123.

3. Vermitsky JP, Self MJ, Chadwick SG, Trama JP, Mordechai E, Adelson ME. 2007. A survey of vaginal flora Candida species isolates from women of different age groups by use of species-specific PCR detection. J Clin Microbiol, 46(4):1501-1503.

4. Gygax, S.E., Vermitsky, J.-P., Self, M.J., Chadwick, S.G., Mordechai, E., Adelson, M.E., and Trama, J.P. 2008. Antifungal Resistance of Candida glabrata Vaginal Isolates and the Development of a qRT-PCR-based Azole Susceptibility Assay. Antimicrob. Agents Chemother. 52(9): 3424-3426.

5. Gygax SE, Vermitsky JP, Self MJ, Mordechai E, Adelson ME, Trama JP. 2008. Antifungal resistance in vaginal Candida clinical isolates. Antimicrob Agents Chemother, manuscript under review.

6.Prasad, A., Mordechai, E., Adelson, M.E., and Gygax, S.E. 2009. PBP4 Polymorphisms Generate Penicillin Tolerance in Group B Streptococcus. Nature Medicine. Manuscript in preparation.

2. Vermitsky, J.-P., Self, M.J., Chadwick, S.G., Katiyar, S.K., Mordechai, E., Adelson, M.E., Edlind, T.D., and Gygax, S.E. 2009. cAMP-PKA kinase Tpk3 negatively regulates Candida glabrata Pdr1. Antimicrob. Agents Chemother. Manuscript in preparation.

1. Vermitsky, J-P., Chadwick, S.G., Self, M.J., Mordechai, E., Adelson, M.E., Nickels, J.T. Jr., and Gygax, S.E. 2009. CgUpc2 is the master regulator of ergosterol biosynthetic genes in Candida glabrata. Antimicrob. Agents Chemother. Manuscript in preparation.

Abstracts & Presentations

1. Gygax SE, Schuyler JA, Trama JP, Mordechai E, Adelson ME. Erythromycin and clindamycin resistance in Group B Streptococcus clinical isolates. 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, December 16- 19, 2005.

2. Gygax SE, Prasad A, Schuyler JA, Trama JP, Mordechai E, Adelson ME. Penicillin tolerance in Group B Streptococcus. 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 26-30, 2006.

3. Gygax SE, Schuyler JA, Trama JP, Adelson ME. A novel β-hemolysin/cytolysin expression phenotype in Group B Streptococcal clinical isolates. 107th American Society of Microbiology General Meeting, Toronto, Canada, May 21-25, 2007.

4. Gygax SE, Prasad A, Schuyler JA, Trama JP, Mordechai E, Adelson ME. Penicillin tolerance in Group B Streptococcus. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, September 17-20, 2007.

5. Edlind TD, Vermitsky JP, Pfaller M, Gygax SE, Katiyar S. Molecular mechanisms behind flucytosine resistance and azoleflucytosine antagonism in Candida glabrata. 9th American Society for Microbiology Conference on Candida and Candidiasis, Jersey City, NJ. March 24-28, 2008.

6. Katiyar S, Vermitsky JP, Gygax SE, Edlind TD. Anatomy of Candida glabrata PdR1, master regulator of azole resistance: evidence for activation by MAP kinase SIt2. 9th American Society for Microbiology Conference on Candida and Candidiasis, Jersey City, NJ. March 24-28, 2008.

7. Vermitsky JP, Self MJ, Katiyar S, Mordechai E, Adelson ME, Edlind TD, Gygax SE. The cAMP protein kinase a signal transduction pathway negatively regulates Pdr1, the master regulator of azole resistance in Candida glabrata. 9th American Society for Microbiology Conference on Candida and Candidiasis, Jersey City, NJ. March 24-28, 2008.

8. Hilbert DW, Paulish TE, Libby EK, Pascal KE, Mordechai E, Adelson ME, Gygax SE, Trama JP. O Serotype, Virulence Factors, Plasmid Replicons, and Antibiotic Resistance of Rectal and Cervico-vaginal Escherichia coli Isolates. 108th American Society for Microbiology General Meeting. Boston, MA. June 1-5, 2008.

9. Vermitsky JP, Katiyar S, Gygax SE, Edlind TD. Multidrug resistance transcription factor Pdr1 is activated by MAP kinase Slt2 and repressed by protein kinase A Tpk3 in the opportunistic yeast Candida glabrata. 2008 Yeast Genetics and Molecular Biology Meeting. Toronto, Canada. July 22-27, 2008.

10. Prasad A, Mordechai E, Adelson ME, Gygax SE. Penicillin tolerance in Group B Streptococcus. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 25-28, 2008.

11. Prasad A, Basu P, Mordechai E, Adelson ME, Gygax SE.. PBP4 Polymorphisms Generate Penicillin Tolerance in Group B Streptococcus. 109th American Society for Microbiology General Meeting. Philadelphia, PA. May 17-21, 2009.

12. Vermitsky JP, Self MJ, Chadwick SG, Katiyar SK, Edlind TD, Gygax SE. 2009. cAMP-PKA kinase Tpk3 negatively regulates Candida glabrata Pdr1. 109th American Society for Microbiology General Meeting. Philadelphia, PA. May 17-21, 2009.

13. Chadwick SG, Mordechai E, Adelson ME, and Gygax SE. Susceptibility profiles of community-associated MRSA isolates from cervicovaginal swab samples. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 12-15, 2009.