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Pharmacogenomics Division
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| Personnel |
| Joe Nickels, Ph.D. - Pharmacogenomics Division Team Leader |
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 2006 – Editorial Board: Analytical Biochemistry.
- 1999-2006 Director, Graduate Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine.
- 2005-2007 Associate Professor, Department of Biochemistry and Molecular Biology, Drexel University College of Medicine.
- 1999-2002 Basil O’Connor Scholar, March of Dimes Foundation.
- 1997-2005 Assistant Professor, Department of Biochemistry and Molecular Biology, Drexel University College of Medicine.
- 1994-97 Postdoctoral Fellow, New Jersey Commission on Cancer Research.
- 1993-97 Post-doctoral fellow, Department of Molecular Biology, Princeton University, Advisor: Jim Broach, Ph.D. Studiedceramide signaling and the role of ceramide-activated protein phosphatase (CAPP) in regulating the yeast cell cycle.
- 1989-93 Ph.D. Microbiology and Molecular Genetics, UMDNJ/Rutgers University. Studied phosphoinositide signaling in the yeast S. cerevisiae. Advisor: George Carman, Ph.D.
- Adhoc manuscript reviewer Journal of Biological Chemistry, Genetics, Molecular and Cellular Biology, Microbiology, Eukaryotic Cell, Current Biology, Molecular Biology of the Cell, Biochmica and Biophysica Acta.
- Adhoc grant reviewer Canadian Research Council, National Science Foundation, Swiss Research Foundation.
- Member of Genetics Society of America, American Association for the Advancement of Science, American Society for Microbiology, American Society for Biochemistry and Molecular Biology.
- Currently isolating novel antifungal targets through uncovering the molecular basis for induced sterol gene expression in response top blocks in sterol biosynthesis in several yeast species.
- Isolating novel protein phosphatase 2A (PP2A) targets through elucidating the role of PP2A and CAPP in cell cycle regulation and endocytosis. These targets may have future potential as drug targets for cancer and diabetes.
- Exploring the role of the putative lipid transporter, Arv1, in sterol trafficking, cardiovascular disease, and polarized growth in yeast and humans.
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| Paula McCourt, Ph.D. |
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 Ph.D. in Molecular & Cell Biology & Genetics from Drexel University College of Medicine. Dissertation: “Novel Functions of Protein Phosphatase 2A in Saccharomyces cerevisiae”.
- Ph.D. supervisor: Joseph T. Nickels, Ph.D.
- B.A. in Biology from Holy Family University. Undergraduate Senior Project: “Isolation of Antibiotic Resistant Gram-negative Bacteria from the Delaware River”.
- Currently investigating the role of sphingolipids in endocytosis; understanding the role of protein phosphatase 2A in regulating the cell cycle in the budding yeast, Saccharomyces cerevisiae.
- Isolating novel PP2A substrates in yeast and humans.
- Exploring the role of human Arv1 in sterol and sphingolipid trafficking.
- Member of the Genetics Society of America.
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| Lyndi M. Rice, Ph.D. |
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 Post-doctoral Research at the Wistar Institute studying the role of histone modifications in genomic silencing in Schizosaccharomyces pombe and the effects of histone variant incorporation into the HSV-1 genome during lytic infection. Mentor: Shelley Berger, Ph.D.
- Ph.D. in Molecular & Cell Biology & Genetics from Drexel University College of Medicine in May, 2005. Dissertation: “The Regulation of Pre-Meiotic DNA replication in Saccharomyces cerevisiae.” Mentor: Joseph T. Nickels, Ph.D.
- B.S. in Biology from Indiana University of Pennsylvania, 2000.
- Currently investigating the role of protein phosphastase 2A (PP2A) in pre-meiotic DNA replication.
Isolating novel PP2A substrates in mammalian cell lines in order to further investigate the role of PP2A in the progression of cancer.
- Examining the role of PP2A in cholesterol synthesis in human tissue culture and Schizosaccharomyces pombe.
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| Christina Gallo, B.S. |
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 Ph.D. candidate in Molecular & Cell Biology & Genetics from Drexel University College of Medicine.
- Graduate thesis work focused on understanding the transcriptional mechanisms regulating sterol biosynthesis in Saccharomyces cerevisiae.
- Thesis advisor: Joseph T. Nickels, Ph.D.
- B.S. in Molecular Biology from Lehigh University.
- Currently isolating novel antifungal drug targets within the sterol and sphingolipid biosynthetic pathways in S. cerevisiae.
- Exploring the potential roles of these drug targets in the initiation and maintenance of cardiovascular disease in humans.
- Member of the Genetic Society of America and the American Association for the Advancement of Science.
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| Jocelyn Nolt, B.S. |
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- Ph.D. candidate in Molecular & Cell Biology & Genetics at Drexel University College of Medicine: Supervisor: Joseph T. Nickels, Ph.D.
- Currently characterizing the role of protein phosphatase 2A (PP2A) in meiosis using the budding yeast, Saccharomyces cerevisiae as a model system.
- Isolating novel cell cycle targets of PP2A in yeast and humans.
- B.S. in Biochemistry & Molecular Biology from Dickinson College, Carlisle, PA.
- Member of the Genetics Society of America and The American Society for Microbiology.
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| Michelle Villasmil, B.S. |
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 Ph.D. candidate in Molecular & Cell Biology & Genetics at Drexel University College of Medicine.- Supervisor: Joseph T. Nickels, Ph.D.
- B.S. in Molecular Genetics from the University of Rochester.
- B.A. in Spanish from the University of Rochester.
- Currently pursuing a structure/function analysis of Arv1 Homology Domain (AHD), in the putative lipid transporter, Arv1, and defining its role in sterol trafficking.
- Determining role of Arv1 in polarized cell growth in S. cerevisiae.
- Determining the molecular role of human Arv1 in sterol and sphingolipid homeostasis and ascertaining its potential as a chemotherapeutic target for cardiovascular disease.
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