Topics in Molecular Pathogenesis and Immunology:

4 credits – Spring semester
Course Directors – Grant Gallagher, Ph.D and Jason Trama, Ph.D.

This course provides the student with a factual understanding of key host/pathogen elements related to the development of human disease. The course will cover major human bacterial, viral and fungal pathogens and their disease-causing mechanisms. In addition, the human immune system is presented in the context of host-defense against infectious and malignant disease. Mechanisms of tumorigenesis and metastasis are explored, as are the strategies and approaches used to develop new therapeutic compounds. Finally, two shorter elements describe the creation, validation and standardization of new molecular diagnostic tools, and the critical evaluation of experimental data. Upon completion of the course, students will have gained a broad overview of the theoretic and practical aspects of the subjects that underlie the laboratory courses they will take in the future.

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Course Distribution:

Week Topic A Topic B Topic C Topic D

1

Immunol

Microbiol

Virology

Statistics

2

Immunol

Microbiol

Virology

Statistics

3

Immunol

Microbiol

Virology

Statistics

4

Immunol

Microbiol

Virology

Statistics

5

Immunol

Microbiol

Virology

Stats (exam)

6

Canc Biol

Drug Discovery

Int Mol Diag

Microbiol

7

Canc Biol

Drug Discovery

Int Mol Diag

Microbiol

8

Canc Biol

Drug Discovery

Int Mol Diag

Microbiol

9

Canc Biol

Drug Discovery Int Mol Diag

Microbiol

10 Canc Biol Drug Discovery I.M.D. (exam) - essays -
11 Virology Immunol Drug Discovery Cancer Biol
12 Virology Immunol Drug Discovery Cancer Biol
13 Virology Immunol Drug Discovery Cancer Biol
14 Virology Immunol Drug Discovery Cancer Biol
15 -- Exam: answer one question from three, for each of the five topics --
Grading: Students are expected to attend and participate in all classes.
Grades will be based upon written essays (due week 10) and a final written examination (week 15):
Class Participation     5%
Statistics and Data Analysis Exam 10%
Introduction to Molecular Diagnosis Exam 10%
Five Topic      (CB, I, M, MBD, V) Essays 25%
Five Topic      (CB, I, M, MBD, V) Exam 50%